Journal
Discover Life
Discover Life is an open access journal publishing research from all fields relevant to biological and biomedical sciences.
The immune system plays a central role in maintaining tissue homeostasis and protecting against disease. From autoimmune disorders to cancer, from neuroimmune interactions to metabolic regulation, the immune cell heterogeneity and functional plasticity are now recognized as the engines driving both protection and pathology.
This collection will spotlight immune cell heterogeneity and functional plasticity across health and disease, positioning them as the conceptual anchors for future research. By moving beyond single disease or single-cell perspectives, we aim to illuminate shared principles that govern diverse immune populations, T cells, macrophages, NK cells, dendritic cells, innate lymphoid cells (ILCs), and beyond.
A central focus of this collection will be on forward-looking perspectives, emphasizing emerging concepts, novel technologies (such as single-cell and spatial omics), and future research directions. We particularly encourage contributions that provide new conceptual frameworks, challenge existing paradigms, and introduce innovative approaches to studying immune regulation and dysfunction.
Topics of interest include:
• Immune cell heterogeneity and plasticity across health and disease
• Mechanisms of immune tolerance and dysfunction in autoimmunity and cancer
• Neuroimmune interactions and immune diversity in neurological disorders
• Metabolic and environmental regulation of immune heterogeneity
• Tissue specific immunity and microenvironmental influences
• Cutting-edge technologies: single-cell, spatial omics, multi-omics, and AI
• Biomarkers and translational applications of immune heterogeneity
Submit your manuscript to this collection through a participating journal.
Journal
Discover Immunity
Discover Immunity is an open access journal publishing research from all fields relevant to human, animal and plant immunology.
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Zhaohui Li, Dr.
Beckman Research Institute of City of Hope, Los Angeles, United States.Dr. Li studied microbiology during his master's degree, focusing on metabolic regulation of docosahexaenoic acid (DHA). While his PhD was focusing on the immune response between virus and host, his postdoctoral career changed to tumor immunology. These research experiences expanded his expertise in various research areas and made him more open to achieving multiple disciplines of scientific research.
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Yun Shi, Dr.
Shanghai Jiao Tong University, Shanghai, China.Dr. Shi is a researcher in immunology and laboratory medicine. Her work focuses on regulatory T cells, immune tolerance, and the mechanisms underlying autoimmune and inflammatory diseases. She has published in journals including Science Advances, Trends in Immunology, Signal Transduction and Targeted Therapy, and Frontiers in Immunology. Her current research explores the molecular regulation of Treg function and its translational potential in human disease.
