The immune system relies on a complex network of receptor-ligand interactions to distinguish self from non-self, maintain immune tolerance, and mount effective responses against infection, malignancy, and foreign tissue.

Submissions open on 24 August 2026.

Neuroinflammation is a central feature of a wide range of neurological and psychiatric conditions, including multiple sclerosis, Alzheimer's disease, Parkinson's disease, stroke, traumatic brain injury, and mood disorders.

The field of inborn errors of immunity (IEI) is advancing at a remarkable pace, driven by next-generation sequencing, functional genomics, and an expanding understanding of the molecular pathways that underpin human immune function. In this Special Issue, we bring together contributions that reflect the breadth of this discipline.

Submissions open on 1 October 2026.

The tumor microenvironment (TME) shapes anti-tumor immunity and influences the success of immunotherapies. Its metabolic alterations profoundly affect immune cell function, fate, and therapeutic response.

Submissions open on 1 November 2026.