Latest research
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Neurostimulationsverfahren in der Behandlung der obstruktiven Schlafapnoe
in HNOEine der häufigsten schlafbezogenen Atmungsstörungen ist die obstruktive Schlafapnoe (OSA), die mit erhöhter kardiovaskulärer Morbidität einhergeht und pathophysiologisch auf dem Kollaps der oberen Atemwege aufgrund eines schlafbedingten reduzierten...
hsa_circ_0001512 orchestrates endothelial dysfunction in obstructive sleep apnea by regulating the miR-4728-3p/MST4/ERK axis
Background Cardiovascular complications of obstructive sleep apnea (OSA) show marked vascular endotype heterogeneity that is not fully captured by the apnea-hypopnea index. We tested whether hsa_circ_0001512 acts as an intermittent hypoxia...
Association of homocysteine and waist-to-height ratio with poor sleep quality in community-dwelling individuals at high risk of stroke: a cross-sectional study based on two community screening rounds in 2015 and 2025
Background Poor sleep quality has been associated with cerebrovascular disease and is increasingly recognised as a potentially modifiable factor relevant to cerebrovascular health. Nevertheless, the prevalence of sleep problems and their...
Lower serum annexin A1 and neurogranin levels in chronic schizophrenia: a case–control study
Background Synaptic dysfunction and immune mechanisms are both implicated in schizophrenia. Annexin A1 (ANXA1) is a glucocorticoid-induced pro-resolving protein and neurogranin (Ng) is a post-synaptic, calmodulin-binding protein studied as a...
Integrating network pharmacology, genetically informed multi-omics and granulosa-cell experiments identifies dauricine and oleanolic acid as candidate CASP3-modulating compounds of Zhi-Bai-Di-Huang-Wan in female pubertal timing
Zhi-Bai-Di-Huang-Wan (ZBDHW) is a traditional Chinese medicine formula clinically used for precocious puberty, but its molecular basis remains unclear. Earlier age at menarche (AAM) reflects advanced female pubertal timing and provides a genetically...
Effects of ventromedial hypothalamic nucleus GAD gene knockdown on growth hormone-releasing hormone neuron transcriptomic profile in female rats
Background Recent studies in male rats identify ventromedial hypothalamic nucleus (VMN)-dorsomedial division (VMNdm) growth hormone-releasing (Ghrh) neurons as a potential target for VMN γ-aminobutyric acid (GABA) control of counterregulatory hormone...
Botulinum toxin for neuromuscular and objective tinnitus subtypes: a systematic review of human studies
Background Tinnitus management remains challenging, particularly in objective, myoclonic, or somatosensory subtypes where conventional therapies show limited benefit. Botulinum toxin (BTX) has been increasingly investigated as a neuromodulatory...
A pilot randomized controlled trial of melatonin supplementation on plasma 2-arachidonoylglycerol, ghrelin, and hedonic appetite intensity in females with overweight/obesity
Hedonic appetite, the motivation to consume palatable foods for pleasure rather than physiological need, may contribute to overweight and obesity, yet few interventions have targeted it. This pilot randomized, placebo-controlled trial examined the...
A phase 2 trial evaluating polysomnography outcomes and safety of lemborexant in Korean adults with insomnia disorder
Lemborexant (LEM), a dual-orexin-receptor-antagonist, was evaluated in this study of Korean participants with insomnia disorder. Study E2006-J082-204 (Study 204), a 1-month, multicenter, double-blind, placebo (PBO)-controlled, parallel-group study,...
Hypothalamus and preoptic area in breeding rodent: a review
Rodent is a diversified group of mammals and characterized by small body, short limb, long tail and incisor teeth. Majority of mammals fall under this category including mice and rats which are commonly used as laboratory animal. Brain of rodent...
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